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Metastatic breast cancer is cancer that has spread to other parts of the body away from the breast, such as the bones or liver. Metastatic urothelial carcinoma is an aggressive cancer with a poor prognosis. Kn026 represents a novel bispecific antibody targeting two distinct her2 epitopes (ecd2 and ecd4), with its structural configuration detailed in supplementary fig

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Trastuzumab is a humanized igg1 monoclonal antibody that targets the her2 receptor (also known as her2/neu) that is found on the cell membrane of epithelial cells. The biparatopic her2 antibody design may enhance target binding and contribute to the observed clinical benefit